The idea of Kreb’s cycle wasn’t recognized in the first place.
How do you react if the top journal of your field rejects your paper?
Bag the most prestigious accolade of your field.
Nature semi-rejected Kreb’s Citric Acid Cycle paper & later he won a Noble Prize.
Hans Krebs was a tenured professor at U Freiberg in Germany.
In the 1930s, he was sacked & had to flee from Germany during the Nazi regime.
The Jewish scientist had training in medicine & chemistry who joined U Sheffield.
In 1937, Krebs & his colleague were experimenting with the heart of a pigeon.
They’re measuring its metabolic rate declination.
Observations have him clues & he formulated the TCA cycle for metabolism.
He sent his finding & the revolutionary paper to Nature for publication.
But Nature refused to publish it immediately, citing a backlog of ‘letters’.
Krebs then sent his work to Enzymologia, a Dutch journal, which was published within 2 months.
Krebs went on to receive a Nobel Prize in 1953 for the discovery of the TCA cycle.
Fun fact? In 1988, an anonymous editor published the refusal letter in Nature.
It was termed as an ‘egregious error’ committed by the top-notch publishing house.